The Darkest Light by Ashley Earley7/7/2023 ![]() Superoxide production and content of the oxidative stress marker nitrotyrosine was higher in MCAs from Eln +/− compared with Eln +/+ mice ( P < 0.05). ![]() Endothelium-dependent dilatation (EDD), assessed by the maximal dilatation to acetylcholine, was ∼40% lower in Eln +/– than Eln +/+ mice in the middle cerebral artery (MCA, P 0.05), indicating that lower NO bioavailability contributed to the impaired EDD in Eln +/– mice. Aortic stiffness, measured by pulse wave velocity, was ∼35% greater in Eln +/– mice than in wild-type ( Eln +/+) mice ( P = 0.04). ![]() We used elastin heterozygote mice ( Eln +/–) as a model of increased large artery stiffness without co-morbidities unrelated to the large artery properties. It has been hypothesized that greater large artery stiffness causes peripheral artery dysfunction however, a cause-and-effect relationship has not previously been established. Advancing age as well as diseases such as diabetes are characterized by both increased large artery stiffness and impaired peripheral artery function. ![]()
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